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目的:探讨转化生长因子β1(TGF-β1)与热休克蛋白70(HSP70)在喉鳞状细胞癌的表达情况及意义。方法:采用免疫组织化学SP法结合计算机图像分析系统对53例喉鳞状细胞癌和48例癌旁组织中TGF-β1和HSP70的表达进行检测。结果:喉鳞状细胞癌组织中TGF-β1和HSP70均有不同程度的表达;喉鳞状细胞癌TGF-β1的表达明显低于癌旁组织(P<0.05);与之相反,喉鳞状细胞癌HSP70的表达明显高于癌旁组织(P<0.05)。喉鳞状细胞癌组织中TGF-β1和HSP70的表达均与肿瘤组织分化程度密切相关(P<0.01或P<0.01),且两者的表达水平呈明显负相关(r=-0.87,P<0.01)。结论:TGF-β1和HSP70的阳性表达与喉鳞状细胞癌组织学分级密切相关,它们共同参与了喉鳞状细胞癌的发生、发展及恶性进程。
Objective: To investigate the expression and significance of transforming growth factor β1 (TGF-β1) and heat shock protein 70 (HSP70) in laryngeal squamous cell carcinoma. Methods: The expressions of TGF-β1 and HSP70 in 53 cases of laryngeal squamous cell carcinoma and 48 cases of paracancerous tissues were detected by immunohistochemical SP method combined with computer image analysis system. Results: The expression of TGF-β1 and HSP70 in laryngeal squamous cell carcinoma was different, and the expression of TGF-β1 in laryngeal squamous cell carcinoma was significantly lower than that in paracancerous tissues (P <0.05). On the contrary, The expression of HSP70 in cell carcinoma was significantly higher than that in paracancerous tissues (P <0.05). The expression of TGF-β1 and HSP70 in laryngeal squamous cell carcinoma was closely related to the degree of tumor differentiation (P <0.01 or P <0.01), and the expression of TGF-β1 and HSP70 was negatively correlated (r = -0.87, P < 0.01). Conclusion: The positive expression of TGF-β1 and HSP70 are closely related to the histological grade of laryngeal squamous cell carcinoma. They all participate in the occurrence, development and malignant process of laryngeal squamous cell carcinoma.