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用比色法测定３８例肾病综合征病人血清唾液酸（ＳＡ）含量，观察其动态变化并与６８例正常人进行比较。结果表明，肾病综合征病人血清ＳＡ含量明显高于正常对照组（Ｐ＜０．００１），活动期ＳＡ含量较恢复期显著增高（Ｐ＜０．００１），血清ＳＡ含量与其尿蛋白含量呈显著正相关（ｒ＝０．６０１），与血浆总蛋白含量呈显著负相关（ｒ＝－０．７４４）。提示血清ＳＡ测定在肾病综合征病人的诊断、病情判断及疗效观察方面有重要意义。
Serum sialic acid (SA) content was measured by colorimetric method in 38 patients with nephrotic syndrome. The dynamic changes were observed and compared with 68 healthy controls. The results showed that the level of serum SA in patients with nephrotic syndrome was significantly higher than that in the normal control group (P <0.001), and the SA content in active stage was significantly higher than that in convalescent stage (P <0.001) (R = 0.601), and negatively correlated with the total plasma protein (r = -0.744). Tip serum SA determination in patients with nephrotic syndrome diagnosis, disease judgment and efficacy observation of great significance.