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目的观察并分析在急性脑梗死患者的临床治疗过程中,应用不同剂量阿托伐他汀钙片的临床疗效。方法 88例急性脑梗死患者,根据患者使用阿托伐他汀钙片剂量的不同分为干预组和常规组,各44例。干预组给予大剂量阿托伐他汀钙片,常规组给予小剂量阿托伐他汀钙片。比较两组临床疗效。结果治疗后,干预组的血清总胆固醇为(3.32±0.63)mmol/L、甘油三酯为(1.37±0.79)mmol/L、低密度脂蛋白为(1.59±0.61)mmol/L、高密度脂蛋白为(1.59±0.39)mmol/L,均优于常规组的(4.14±0.56)、(1.79±0.81)、(3.06±0.55)、(0.97±0.34)mmol/L,差异具有统计学意义(P<0.05)。结论大剂量的阿托伐他汀钙片可以使血脂的水平得到明显下降,有效稳定了斑块,显著降低了心脑血管病的风险,在临床上应积极的予以应用。
Objective To observe and analyze the clinical efficacy of different doses of atorvastatin in the clinical treatment of patients with acute cerebral infarction. Methods A total of 88 patients with acute cerebral infarction were divided into intervention group and conventional group according to the dosage of atorvastatin calcium tablets in 44 patients. The intervention group received high-dose atorvastatin calcium tablets, and the conventional group received low-dose atorvastatin calcium tablets. The clinical efficacy of the two groups were compared. Results After treatment, serum total cholesterol (3.32 ± 0.63) mmol / L, triglyceride (1.37 ± 0.79) mmol / L and low density lipoprotein (1.59 ± 0.61) mmol / L and high density lipid (1.59 ± 0.39) mmol / L, which were significantly higher than those in the control group (4.14 ± 0.56, 1.79 ± 0.81, 3.06 ± 0.55 and 0.97 ± 0.34 mmol / L, respectively) P <0.05). Conclusion High-dose atorvastatin calcium tablets can significantly reduce the level of blood lipids, effectively stabilize the plaque, significantly reduce the risk of cardiovascular and cerebrovascular disease, which should be actively applied in clinical practice.