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目的探讨三阴性乳腺癌(TNBC)的临床病理特征。方法回顾性分析4年间资料完整的3 8例TNBC患者临床资料,包括患者的一般状况、病理特点、分子标志物、复发与转移状况,并与同期非TNBC进行比较。结果≤35岁的患者在TNBC及非TNBC中分别占21.05%(8/38)和5.14%(15/292)(P<0.05)。TNBC组中有淋巴结转移者60.53%(23/38),高于非TNBC的43.49%(127/292)(P<0.05),TNBC组中组织学III级者52.63%(20/38)高于非TNBC组的35.27%(103/292)(P<0.05),TNBC中有瘤周脉管侵犯者占31.58%(12/38)高于非TNBC的15.41%(45/292)(P<0.05)。TNBC组表皮生长因子受体(EGFR)阳性率、血管内皮生长因子(VEGF)阳性率、E-钙黏附蛋白(E-cad)异常表达率分别为81.58%(31/38),78.95%(30/38),65.79%(25/38),高于非TNBC组的39.73%(116/292),61.30%(179/292),48.29%(141/292)(均P<0.05)。远处转移率在TNBC组中分别为2 3.6 8%(9/3 8),非TNBC为1 1.9 9%(3 5/2 9 2),差异有统计学意义(P<0.05)。结论 TNBC较多见于年轻患者,浸润转移率高,预后不良。
Objective To investigate the clinicopathological features of triple negative breast cancer (TNBC). Methods The clinical data of 38 patients with TNBC, including the general status, pathological features, molecular markers, recurrence and metastasis, were retrospectively analyzed and compared with the non-TNBC in the same period. Results Patients ≤35 years of age accounted for 21.05% (8/38) and 5.14% (15/292) respectively in TNBC and non-TNBC (P <0.05). TNBC group had lymph node metastasis 60.53% (23/38), higher than non-TNBC 43.49% (127/292) (P <0.05), TNBC group histological grade III 52.63% (20/38) higher than 35.27% (103/292) in non-TNBC group (P <0.05), 31.58% (12/38) in TNBC group were higher than 15.41% (45/292) in non-TNBC group (P <0.05) ). The positive rate of epidermal growth factor receptor (EGFR), the positive rate of vascular endothelial growth factor (VEGF) and the abnormal expression of E-cadherin in TNBC group were 81.58% (31/38) and 78.95% (30.95%) /38)65.79%(25/38), higher than non-TNBC group 39.73% (116/292), 61.30% (179/292), 48.29% (141/292) (all P <0.05). The distant metastasis rate was 23.6% (9/3 8) in TNBC group and 1 1.99% (3 5/2 9 2%) in non-TNBC group, the difference was statistically significant (P <0.05). Conclusion TNBC is more common in young patients with high infiltration and metastasis rate and poor prognosis.