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目的 研究P 糖蛋白在膀胱移行细胞癌中的表达及其在肿瘤复发中的意义。方法 应用S ABC免疫组织化学方法检测 80例膀胱移行细胞癌组织和 2 0例正常膀胱粘膜组织中P 糖蛋白的表达。结果 膀胱移行细胞癌组织P 糖蛋白表达阳性率明显高于正常膀胱粘膜组织 (P <0 .0 1) ,灌注化疗后复发肿瘤P 糖蛋白的阳性表达率明显高于初发肿瘤 (P <0 .0 1)。结论 P 糖蛋白介导的多药耐药是膀胱癌腔内灌注化疗失败、肿瘤复发的重要原因
Objective To study the expression of P glycoprotein in bladder transitional cell carcinoma and its significance in tumor recurrence. Methods S ABC immunohistochemical method was used to detect the expression of P glycoprotein in 80 cases of bladder transitional cell carcinoma and 20 cases of normal bladder mucosa. Results The positive rate of P glycoprotein expression in bladder transitional cell carcinoma was significantly higher than that in normal bladder mucosa (P < 0.01). The positive expression rate of P glycoprotein in recurrent tumor after perfusion chemotherapy was significantly higher than that in primary tumor (P <0. .0 1). Conclusion P-glycoprotein-mediated multidrug resistance is an important cause of failure of intraluminal infusion chemotherapy and tumor recurrence in bladder cancer.