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目的:探讨血管活性肠肽(VIP)在变应性鼻炎发病中的作用。方法:采用放射免疫分析法测定45例变应性鼻炎患者变应原鼻粘膜激发试验前后血浆及鼻分泌物中 VIP 含量及其变化,和健康对照组相比。结果:健康组鼻分泌物中 VIP 明显高于血浆中的浓度(P<0.05)。变应性鼻炎组血浆中 VIP 明显高于正常组(P<0.05),变应原鼻粘膜激发实验后血浆 VIP 含量明显高于激发前(P<0.05),而鼻分泌物中 VIP 各组间均无显著差异。结论:内源性 VIP 可能参与了变应性鼻炎的病理生理过程。
Objective: To investigate the role of vasoactive intestinal peptide (VIP) in the pathogenesis of allergic rhinitis. Methods: The levels of VIP and its changes in plasma and nasal secretions before and after allergic rhinitis in 45 patients with allergic rhinitis were measured by radioimmunoassay. Compared with healthy controls, Results: VIP in nasal secretions of healthy group was significantly higher than that in plasma (P <0.05). The VIP in plasma of allergic rhinitis group was significantly higher than that in normal group (P <0.05). The content of VIP in allergic rhinitis group was significantly higher than that before stimulation (P <0.05) No significant difference. Conclusion: Endogenous VIP may be involved in the pathophysiological process of allergic rhinitis.