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目的检测食管鳞癌组织中乏氧诱导因子-1α(HIF-1α)、表皮生长因子受体(EGFR)和血管内皮生长因子165b(VEGF165b)的表达,并探讨三者间在食管鳞癌发生发展中的关系。方法应用免疫组织化学SP法检测143例食管鳞状细胞癌组织中HIF-1α、EGFR和VEGF165b的表达。结果食管鳞癌组织中HIF-1α、EGFR和VEGF165b的阳性表达率分别为43.4%、58.0%和13.3%;其中HIF-1α阳性表达率与EGFR阳性表达率呈正相关关系(r=0.272,P=0.001),与VEGF165b阳性表达率呈负相关关系(r=-0.203,P=0.015)。结论HIF-1α、EGFR和VEGF165b在食管鳞癌的发生发展中起重要作用,食管鳞癌中HIF-1α的表达与EGFR及VEGF165b的表达存在相关性。
Objective To detect the expression of hypoxia-inducible factor-1α (HIF-1α), epidermal growth factor receptor (EGFR) and vascular endothelial growth factor 165b (VEGF165b) in esophageal squamous cell carcinoma In the relationship. Methods The expression of HIF-1α, EGFR and VEGF165b in 143 cases of esophageal squamous cell carcinoma was detected by immunohistochemical SP method. Results The positive rates of HIF-1α, EGFR and VEGF165b in esophageal squamous cell carcinoma were 43.4%, 58.0% and 13.3%, respectively. The positive rate of HIF-1α was positively correlated with the positive rate of EGFR (r = 0.272, P = 0.001), which was negatively correlated with the positive rate of VEGF165b (r = -0.203, P = 0.015). Conclusion HIF-1α, EGFR and VEGF165b play an important role in the development of esophageal squamous cell carcinoma. The expression of HIF-1α in esophageal squamous cell carcinoma is correlated with the expression of EGFR and VEGF165b.