论文部分内容阅读
目的探讨妇科恶性肿瘤根治术后发生下肢深静脉血栓(LEDVT)的高危因素和保护因素。方法收集实施妇科恶性肿瘤根治术患者122例,分为研究组(发生LEDVT组)及对照组(未发生LEDVT组)各61例。比较两组间共19个因素的临床资料,分析高危因素和保护因素。结果 LEDVT在各疾病组间发生率的差异无统计学意义(P>0.05)。单因素分析显示,体重指数、术中失血量、术后连续卧床时间、术后血小板总数、术后凝血酶原时间(PT)、术后活化部分凝血活酶时间(APTT)、术后纤维蛋白原(FIB)在两组间的差异均具有统计学意义(P<0.05)。多因素分析显示,术后血小板总数及PT的差异无统计学意义(P>0.05)。术后APTT、体重指数、术中失血量、术后连续卧床时间、术后FIB与LEDVT的发生具有相关性OR=0.105、3.421、4.975、6.584、8.19,P<0.05)。结论 1体重指数、术中失血量、术后连续卧床时间、术后FIB与妇科恶性肿瘤根治术后LEDVT的发生呈正相关,可能是LEDVT的高危因素,其中术后FIB可能是LEDVT重要的影响因素。2术后APTT与LEDVT的发生呈负相关,提示术后APTT>27.55s可能是LEDVT的保护因素。
Objective To investigate the risk factors and protective factors of lower extremity deep venous thrombosis (LEDVT) after radical surgery of gynecologic malignancies. Methods A total of 122 patients undergoing radical resection of gynecological malignant tumors were collected and divided into study group (LEDVT group) and control group (61 cases without LEDVT group). The clinical data of 19 factors between the two groups were compared to analyze the risk factors and protective factors. Results There was no significant difference in the incidence of LEDVT among various disease groups (P> 0.05). Univariate analysis showed that body mass index, intraoperative blood loss, postoperative continuous bed rest, postoperative total platelet count, postoperative prothrombin time (PT), postoperative activated partial thromboplastin time (APTT), postoperative fibrin The differences of FIB between the two groups were statistically significant (P <0.05). Multivariate analysis showed that the total number of postoperative platelets and PT was no significant difference (P> 0.05). Postoperative APTT, body mass index, intraoperative blood loss, postoperative continuous bed rest, postoperative FIB and LEDVT were associated OR = 0.105,3.421,4.975,6.584,8.19, P <0.05). Conclusion 1 Body mass index, intraoperative blood loss, continuous postoperative bed rest, postoperative FIB and gynecological malignant tumor after radical prostatectomy was positively correlated with the occurrence of LEDVT, which may be risk factors for LEDVT, of which postoperative FIB may be LEDVT important influencing factors . 2 APTT was negatively correlated with the occurrence of LEDVT, suggesting that postoperative APTT> 27.55s may be the protective factor of LEDVT.