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目的:对变应原特异性免疫治疗(皮下注射)起效时间进行分析。方法:选择对尘螨过敏的变应性鼻炎患者64例,在不给予辅助治疗的情况下行特异性免疫治疗(皮下注射)。每周随访,以症状评分的有效下降作为特异性免疫治疗有效的标准,记录起效时间,并检测治疗前和治疗起效时的血清IL-4浓度。结果:64例患者治疗后开始起效的时间分别在9～17周之间,平均为12.6周。治疗后患者血清IL-4水平较治疗前有下降,但和治疗前比较差异无显著性(P>0.05)。结论:特异性免疫治疗起效时间平均为12.6周,即治疗后约3个月开始发挥作用。
Objective: To analyze the onset time of allergen-specific immunotherapy (subcutaneous injection). Methods: Sixty-four patients with allergic rhinitis allergic to dust mite were selected and immunostimulated (subcutaneously) with no adjuvant therapy. Weekly follow-up, the effective decline in symptom scores as a specific immunotherapy effective standard, record the onset time, and test serum concentrations of IL-4 before and during treatment. Results: The onset time of 64 patients after treatment began at 9-17 weeks with an average of 12.6 weeks. After treatment, serum IL-4 level decreased compared with that before treatment, but there was no significant difference between before and after treatment (P> 0.05). CONCLUSIONS: The mean time to onset of specific immunotherapy was 12.6 weeks, which started approximately 3 months after treatment.