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目的:探讨不同部位骨密度(BMD)与胸主动脉钙化(TAC)之间的相关性。方法:纳入2014年2月到2016年10月所有在中山大学孙逸仙纪念医院住院的符合入选标准的骨质疏松(OP)患者共78例,纳入同期临床基本资料匹配的非骨质疏松(NOP)患者50例。收集患者的临床资料以及血清生化指标,通过CT扫描和Agatston积分评价TAC程度,采用双能X线骨密度仪测量腰椎(L1-L4)、左侧股骨颈、左侧全髋的BMD,并分析不同部位BMD与TAC的相关性。结果:与NOP组相比,OP组TAC发生率明显升高(86.4%比64.7%,P<0.05),且TAC积分更高[284(8,1429)比46(0,784),P<0.05];OP组的体重指数(BMI)和血清白蛋白(ALB)较低(P<0.05)。相关分析发现,腰椎、左侧股骨颈、左侧全髋的BMD均与BMI、ALB呈正相关(P<0.05),与年龄呈负相关(P<0.01)。股骨颈BMD与TAC有显著相关性(r=-0.248,P<0.05)。结论:股骨颈BMD与TAC呈负相关,股骨颈BMD可能为血管钙化的重要预测因子。
Objective: To investigate the correlation between different parts of bone mineral density (BMD) and thoracic aortic calcification (TAC). Methods: A total of 78 patients with osteoporosis (OP) who were hospitalized at Sun Yat-sen Memorial Hospital of Sun Yat-sen University from February 2014 to October 2016 were included in the study. Non-osteoporosis (NOP) 50 patients. The clinical data of patients and serum biochemical parameters were collected. The degree of TAC was assessed by CT scan and Agatston score. The BMD of lumbar vertebrae (L1-L4), left femoral neck and left total hip were measured by dual energy X-ray absorptiometry. Correlation between BMD and TAC in Different Parts. Results: Compared with NOP group, the incidence of TAC in OP group was significantly higher (86.4% vs 64.7%, P <0.05), and the TAC score was higher [284 (8,1429) vs 46 (0,784), P <0.05] Body mass index (BMI) and serum albumin (ALB) were lower in OP group (P <0.05). Correlation analysis showed that BMD of lumbar spine, left femoral neck and left hip were positively correlated with BMI and ALB (P <0.05), but negatively correlated with age (P <0.01). Femoral neck BMD and TAC had a significant correlation (r = -0.248, P <0.05). CONCLUSION: BMD of femoral neck is negatively correlated with TAC, and BMD of femoral neck may be an important predictor of vascular calcification.