Survivin是凋亡抑制蛋白家族的新成员,Survivin具有肿瘤特异性,只表达于肿瘤和胚胎组织,且与肿瘤细胞的分化增殖及浸润转移密切相关。并可能成为肿瘤靶相治疗的一个良好的靶基因蛋白。本文综述了Survivin的生物学特性及其与肿瘤浸润转移的关系,着重阐述了其在头颈部肿瘤中的表达及意义,并提出了目前存在的问题与展望。 Survivin is a new member of the apoptosis-inhibitory protein family. Survivin is tumor-specific and only expressed in tumor and embryonic tissues. It is closely related to the differentiation, proliferation, invasion and metastasis of tumor cells. And may become a good target gene protein for tumor target therapy. This review summarizes the biological characteristics of Survivin and its relationship with tumor invasion and metastasis, and emphatically expounds its expression and significance in head and neck cancer, and puts forward the existing problems and prospects.