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目的探讨低分子肝素联合单硝酸异山梨酯治疗不稳定型心绞痛(UAP)的疗效。方法随机将105例不稳定型心绞痛住院患者分为两组:治疗组(采用低分子肝素联合单硝酸异山梨酯治疗)55例,对照组50例。结果治疗组总有效率90·91%。对照组50例,总有效率70%,两组临床疗效与心电图改善总有率对比,经统计学处理(χ2=7·4362,P<0·01),差异有统计学意义。结论低分子肝素联合单硝酸异山梨酯治疗能迅速控制UAP,解除大部分患难的临床症状,且无严重出血等不良反应,不必监测APTT,临床使用方便,安全可靠,疗效满意,具有临床推广应用价值。
Objective To investigate the effect of low molecular weight heparin combined with isosorbide mononitrate in the treatment of unstable angina pectoris (UAP). Methods Randomly divided 105 patients with unstable angina pectoris into two groups: 55 cases in the treatment group (treated with low molecular weight heparin combined with isosorbide mononitrate) and 50 cases in the control group. Results The total effective rate in the treatment group was 90.91%. The control group of 50 patients, the total effective rate was 70%. The clinical curative effect of the two groups was compared with the total electrocardiogram improvement rate. The difference was statistically significant (χ2 = 7.4362, P <0.01). Conclusions Low molecular weight heparin combined with isosorbide mononitrate can rapidly control UAP, relieve the clinical symptoms of most of the patients without serious adverse reactions such as hemorrhage, without monitoring APTT. It is safe and reliable in clinical application and has satisfactory curative effect and clinical application value.