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目的:优选仙灵骨葆胶囊中丹参、补骨脂提取工艺。方法:采用正交试验的方法,以丹参中丹酚酸B、丹参酮ⅡA、补骨脂中补骨脂素、异补骨脂素的含量为指标,多指标综合评分法处理数据,优化提取工艺中乙醇浓度、溶剂倍数、提取时间、提取次数4个因素。结果:丹参、补骨脂最佳合提工艺为加入8倍量70%乙醇,提取2次,每次1.5 h。结论:优选的丹参、补骨脂提取工艺稳定可行。
Objective: To optimize Xianling Gubao capsule Salvia, psoralen extraction process. Methods: The orthogonal test was used to determine the contents of salvianolic acid B, tanshinone ⅡA, psoralen and isopsoralen in Salvia miltiorrhiza Bunge. The data were processed by the multi-index comprehensive score method to optimize the extraction process Medium ethanol concentration, solvent multiples, extraction time, the number of extraction 4 factors. Results: The optimal combination of Salvia miltiorrhiza and Psoralen was as follows: adding 8 times the amount of 70% ethanol and extracting twice for 1.5 hours. Conclusion: The optimal extraction process of Salvia miltiorrhiza and Psoralen is stable and feasible.