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目的：探讨小儿原发性肾病综合症血小板及体积参数引起血液高凝的原因。方法：用血细胞分析仪测定４２例小儿原发性肾病综合征（ＮＳ）患者血小板计数及体积参数。结果：ＮＳ患者血小板计数（ＰＬＴ），血小板压积（ＰＣＴ）较正常对照组明显升高；平均血小板体积（ＭＰＶ），血小板分布宽度（ＰＤＷ），大血小板比率（Ｐ－ＬＣＲ）明显降低（Ｐ＜０．０５）；血小板分布直方图明显左移，体积均－性增强。结论：提示血小板增多及体积参数改变是导致ＮＳ患者血液高凝状态的重要因素之一。
Objective: To investigate the causes of blood coagulation caused by platelets and volume parameters in children with primary nephrotic syndrome. Methods: Platelet count and volumetric parameters of 42 children with primary nephrotic syndrome (NS) were determined by hematology analyzer. Results: The mean platelet count (PLT) and platelet pressure (PCT) in patients with NS were significantly higher than those in normal controls. The mean platelet volume (MPV), platelet distribution width (PDW) and P-LCR <0.05). The histogram of platelet distribution shifted to the left significantly and the volume increased uniformly. Conclusion: It is suggested that the increase of thrombocytopenia and the change of volume parameters are one of the important factors that cause the hypercoagulability of blood in NS patients.