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对134例甲状腺功能亢进症(简称甲亢)血清骨钙素(osteocalcin,BGP)、Ca、P、AKP、桡骨及尺骨骨矿物质含量(BMC)、骨密度(BD)进行了测定。BGP水平高于相应年龄、性别的对照组(333例,P<0.01)。4.9％低血钙、6.0％低血磷、10.8％AKP升高、56％的患者BMC及BD水平降低。BGP与甲亢病程呈正相关关系,治疗前升高最显著,随病情好转逐渐降低。血清BGP测定可作为甲亢骨病的较敏感可靠的诊断指标,而AKP测定的敏感性较差。
134 cases of hyperthyroidism serum BGP, Ca, P, AKP, radius and ulna bone mineral content (BMC), bone mineral density (BD) were determined. BGP level was higher than the corresponding age and gender control group (333 cases, P <0.01). 4.9% hypocalcemia, 6.0% hypophosphatemia, 10.8% AKP increased, 56% of patients with decreased BMC and BD levels. BGP and hyperthyroidism duration was positively correlated, the most significant increase before treatment, with the condition improved gradually reduced. Determination of serum BGP can be used as a more sensitive and reliable diagnostic indicators of hyperthyroidism bone disease, and AKP determination of the sensitivity of poor.