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在饲料中加入氨基比林和NaNO_2各2g/kg饲与Wistar大鼠38周后诱发出肝、肺及肾脏肿瘤,其中以肝肿瘤的发生率为100％(17/17),大鼠平均寿命195天。而同时给予沙棘汁饮用的大鼠其肿瘤发生较晚,发癌率较低(88％,15/17),平均寿命270天,显著长于对照组和单纯抗坏血酸组(P<0.01),且肝脏癌变范围较小,病变较轻。结果表明,沙棘汁能有效地阻断N-亚硝基化合物在大鼠体内合成及诱癌,其防癌效果优于等量的抗坏血酸。
Liver, lung and kidney tumors were induced by adding 2 g / kg of aminopyrine and NaNO 2 each to feed and Wistar rats for 38 weeks. The incidence of liver tumors was 100% (17/17), and the average life span 195 days. However, rats given seabuckthorn juice drinking at the same time developed tumors with relatively low incidence of cancer (88%, 15/17) and average life expectancy of 270 days, significantly longer than that of the control group and pure ascorbate group (P <0.01) A small range of cancer, lesion lesion. The results showed that sea buckthorn juice can effectively block the N-nitroso compounds in vivo synthesis and induced cancer, the anti-cancer effect is better than the equivalent amount of ascorbic acid.