Henry Bence Jones 发现多发性骨髓瘤患者存在一种特殊热学性质的尿蛋白已有百年历史。Edelman 和 Gally 证明这种奇异的蛋白质是免疫球蛋白分子的轻链,Kappa 或Lambda 链。现知正常尿中含有非常少量的来源于多克隆(polyclonal)的游离 Kappa 和Lambda 轻链混合物,但本斯.琼斯(简称本·琼)蛋白尿只能表示有 Kappa 型或 Lambda型的单克隆轻链。本·琼蛋白是最阜知道的一种恶性肿瘤生物学标志。长期以来,本·琼蛋白尿只被看 Henry Bence Jones found that there is a hundred years history of urinary protein with a special thermal property in patients with multiple myeloma. Edelman and Gally proved that this singular protein is a light chain, Kappa or Lambda chain of an immunoglobulin molecule. It is known that normal urine contains a very small amount of polyclonal free Kappa and Lambda light chain mixtures, but Benson Jones’ proteinuria can only indicate a Kappa or Lambda-type monoclonal Light chain. Ben Joan protein is the most learned of a malignant tumor biological markers. For a long time Benjagin Urine was only seen