【摘 要】
：
A derivative of Brevianamide F,(3S,8aR)-3-((1-allyl-1H-3-indolyl)methyl)-hexa-hy-dropyrrolo[1,2-a ]pyrazine-1,4-dione,was synthesized and characterized by 1H NM
【机 构】
：
College of Chemical and Pharmaceutical Engineering,Hebei University of Science& Technology,Shijiazhu
论文部分内容阅读
A derivative of Brevianamide F,(3S,8aR)-3-((1-allyl-1H-3-indolyl)methyl)-hexa-hy-dropyrrolo[1,2-a ]pyrazine-1,4-dione,was synthesized and characterized by 1H NMR,13C NMR and confirmed by X-ray crystal structure analysis.This compound crystallizes in orthorhombic system,space group P212121 with a = 9.59590(10),b = 12.70430(10),c = 14.5425(2)(A),V=1772.86(3)(A)3,Z= 4,μ(CuKa)= 0.712 mm-1,Dc = 1.279 g/cm3,16019 reflections measured(9.24°≤2θ≤ 147.28°),3524 uoique(Rint = 0.0309,Rsigma= 0.0175)which were used in all calculations.The final R = 0.0567(l ＞ 2σ(I))and wR = 0.1411(all data).The structure exhibits intermolecular hydrogen bonds typed O-H 0,leading to the formation of one-dimensional chains.The title compound was tested for inhibitory activity toward B-16,C6,RM-l and BV-2 cancer celllines.
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