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目的:评价每日2次注射地特胰岛素对于难治性2型糖尿病患者血糖控制疗效及安全性。方法:将50例已经使用诺和锐联合诺和平治疗仍血糖控制未达标的2型糖尿病患者,随机分为对照组和试验组,每组25例,各自保留三餐时注射诺和锐,对照组给予每日一次甘精胰岛素注射,试验组予以每日2次地特胰岛素注射,3个月后观察记录各项指标的变化情况。结果:2组经治疗后,2组患者在空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)等指标均较治疗前有显著下降(P<0.05),空腹C肽(FC-P)水平有明显升高(P<0.05),而组间比较试验组在FBG、2hPG、HbA1c显著性低于对照组,FC-P水平显著性高于对照组;对照组3倍血糖标准差(SD)大于血糖平均值(MBG),试验组3倍SD小于MBG。结论:每日2次注射地特胰岛素对难治性2型糖尿病患者血糖控制达标,抑制血糖波动更具有有效性。
Objective: To evaluate the efficacy and safety of dextromethorphan injection twice daily in the treatment of type 2 diabetes in patients with refractory glycemic control. Methods: Fifty patients who had been treated with Novolin and Novolin for treatment of non-compliance type 2 diabetes were randomly divided into control group and experimental group, with 25 cases in each group. Groups were given insulin glargine once a day. The test group was given insulin injection twice daily, and the change of each index was observed and recorded after 3 months. Results: After treatment, the fasting blood glucose (FBG), 2hPG and HbA1c in two groups were significantly lower than those before treatment (P <0.05), the fasting C peptide (P <0.05). However, the levels of FBG, 2hPG and HbA1c in the two groups were significantly lower than those in the control group (P <0.05), and the levels of FC-P in the control group were significantly higher than those in the control group Blood glucose standard deviation (SD) is greater than the average blood glucose (MBG), 3 times the experimental group SD is less than MBG. CONCLUSION: Dextrins injected twice daily achieves standard of glycemic control in patients with refractory type 2 diabetes, and is more effective in inhibiting blood glucose fluctuation.