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目的采用尿道膜“一杯法”对慢性前列腺炎进行分型诊断,探讨其诊断准确性,安全性及费用。方法慢性前列腺炎患者180例,随机选择其中60例进行“四杯法”检查;另外120例随机分入“一杯法”试验组(60例)和安慰剂组(60例)进行双盲研究;采集受试者的尿液和前列腺按摩液进行镜检和细菌学检查;同时对患者进行疼痛评分,收集受试者处理前后血液样本行血常规和肝肾功能检查,进行安全性评估;收集“四杯法”和“一杯法”的操作步骤和费用数据;结果 “一杯法”试验组Ⅱ型、ⅢA型和ⅢB型检出率分别为7.14%、48.22%和44.64%,“四杯法”组Ⅱ型、ⅢA型和ⅢB型分别为15.00%、46.67%和38.33%,两组数据比较差异无统计学意义(P>0.05)。“一杯法”安慰剂组Ⅱ型、ⅢA型和ⅢB型诊断准确率分别为43.33%、36.67%和20.00%。“一杯法”试验组、“四杯法”组与“一杯法”安慰剂组Ⅱ型和ⅢB型比较,差异有统计学意义(P<0.05)。“一杯法”两组受试者血常规、肝肾功能均在正常范围内,疼痛评分分别为(2.90±1.29)分和(3.00±1.05)分,差异无统计学意义(P>0.05)。“一杯法”法操作步骤和费用明显少于“四杯法”。结论尿道膜“一杯法”能更准确对慢性前列腺炎进行分型诊断,减少因假阳性而导致的误诊,且操作简化,费用低。
Objective To evaluate the diagnostic accuracy, safety and cost of diagnosis of chronic prostatitis by using the urethral membrane “one cup method”. Methods One hundred and eighty patients with chronic prostatitis were randomly selected, and 60 of them were randomly selected for “four-cup method.” Another 120 patients were randomly assigned to “one-cup test” (60 cases) and placebo group Double-blind study; urine and prostate massage fluid were collected for microscopic examination and bacteriological examination; patients were also scored for pain and blood samples were collected before and after treatment for blood tests and liver and kidney function tests for safety The results showed that the detection rates of type Ⅱ, type ⅢA and type ⅢB in experimental group were 7.14% and 48.22, respectively % And 44.64%, respectively. There was no significant difference between the two groups (P> 0.05) in the “four cups method” group Ⅱ, ⅢA and ⅢB type respectively 15.00%, 46.67% and 38.33%. The diagnostic accuracy of “one cup method” placebo group Ⅱ, ⅢA and ⅢB type were 43.33%, 36.67% and 20.00% respectively. The difference between the “one cup” test group, the “four cup method” group and the “one cup method” “placebo group Ⅱ and ⅢB type was statistically significant (P <0.05). The blood test, liver and kidney function of the two groups of subjects were within the normal range, and the pain scores were (2.90 ± 1.29) and (3.00 ± 1.05) points respectively, with no significant difference (P> 0.05 ). ”One cup method “ method operation steps and costs significantly less than ”Four cups method “. Conclusions The urethral membrane ”one cup method " can diagnose the type of chronic prostatitis more accurately and reduce the misdiagnosis caused by false positives, and the operation is simplified and the cost is low.