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目的:调查我院门诊功能性消化不良(FD))患者的抑郁症,为心理治疗FD提供依据。方法:以DSM-Ⅳ为标准诊断抑郁症,Zung抑郁自评量表评价其严重程度。将伴抑郁的FD分为3组:对照(常规内科治疗)、氟西汀、多虑平组,随访12周,以FD症状计分及Zung积分减少50％或以上为治疗有效。结果:1.158例FD中43例诊断为抑郁症,其发生率为27.22％,2.氟西汀和多虑平治疗的有效率分别为78.5％(11/14)和72.33％(8/11),其FD症状分和Zung积分明显下降,与对照有显著性差异(P<0.001。结论:FD伴随的抑郁症发生率高,抗抑郁治疗能有效地改善抑郁和消化不良症状,治疗首选SSRIs。
Objective: To investigate the depression of functional dyspepsia (FD) in our hospital) and provide the basis for psychological treatment of FD. Methods: Depression was diagnosed with DSM-Ⅳ as standard, and Zung depression self-rating scale was used to evaluate its severity. FD patients with depression were divided into three groups: control (conventional medical treatment), fluoxetine, doxepin group, followed up for 12 weeks, with FD symptom scores and Zung points decreased by 50% or more for the treatment of effective. Results: 43 cases of 1.158 cases of FD were diagnosed as depression, the incidence was 27.22%, 2. The effective rates of fluoxetine and doxepin were 78.5% (11/14) and 72.33% (8/11) respectively, (P <0.001) .Conclusion: The incidence of depression associated with FD is high, antidepressant treatment can effectively improve the symptoms of depression and indigestion, and the treatment of preferred SSRIs.