脂肪细胞的分化是在多种转录因子的精细调控下完成的。脂肪细胞分化及发育异常会导致能量代谢失衡,并引起肥胖、脂肪营养不良及糖尿病等临床表现。而伴中心性肥胖的2型糖尿病很可能是由于脂肪组织分化障碍,导致不能产生足够数量的成熟脂肪细胞来容纳过多的能量,从而引起生脂压力转移至肝、肌肉等其他器官,造成脂肪的异位沉积,进而诱发糖尿病。 Adipocyte differentiation is accomplished under the fine control of multiple transcription factors. Adipocyte differentiation and dysplasia can lead to imbalance of energy metabolism and lead to clinical manifestations of obesity, lipodystrophy and diabetes. Type 2 diabetes with central obesity is likely to be due to adipose tissue dysfunction, resulting in not being able to produce enough mature adipocytes to hold too much energy, causing fat transfer to liver, muscle and other organs, resulting in fat Ectopic deposition, and then induce diabetes.