目的检测类风湿关节炎(RA)患者血清中免疫球蛋白(IG)、补体(C)、类风湿因子(RF)、血沉(ESR)和C反应蛋白(CRP)水平变化,探讨这些检测指标在RA诊断和疗效评价中的价值。方法分别检测60例正常对照组和95例RA活动组及82例缓解组患者的各项指标,并对其进行分析。结果 RA活动组和缓解组与正常对照组比较血清IG、C、RF、ESR和CRP水平均明显升高,差异有统计学意义(P<0.01);RA活动组与缓解组相比各项指标差异有统计学意义(P<0.05)。结论 RA的IG、C、RF和CRP水平与患者疾病的活动性密切相关,对临床诊断、疗效评价和预后判断具有重要临床意义。 Objective To detect the levels of serum immunoglobulin, complement, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in patients with rheumatoid arthritis (RA) RA diagnostic and efficacy evaluation of the value. Methods The indexes of 60 normal controls, 95 active RA patients and 82 remission patients were detected and analyzed. Results The levels of serum IG, C, RF, ESR and CRP in RA active group and remission group were significantly higher than those in normal control group (P <0.01). Compared with remission group, The difference was statistically significant (P <0.05). Conclusions The levels of IG, C, RF and CRP in RA are closely related to the activity of patients’ diseases, and have important clinical significance for clinical diagnosis, curative effect evaluation and prognosis.