论文部分内容阅读
为进一步明确急性肾小球肾炎(AGN)的发病机理,我们检测了AGN患儿外周血淋巴细胞白细胞介素-2(IL-2)活性及白细胞介素2受体(IL-2R)表达能力。结果表明AGN患儿外周血淋巴细胞IL-2活性低于对照组(P<0.05);经PHA刺激激活后的淋巴细胞IL-2R表达能力低于对照组(P<0.005);而未经PHA刺激的淋巴细胞IL-2R表达能力高于对照组(P<0.01)。提示该病的发生是由于患儿T淋巴细胞功能不足,免疫应答能力下降:T—B淋巴细胞功能失调,机体免疫调节功能紊乱的结果。
To further clarify the pathogenesis of acute glomerulonephritis (AGN), we examined the peripheral blood lymphocyte interleukin-2 (IL-2) activity and interleukin 2 receptor (IL-2R) expression in AGN children . The results showed that IL-2 activity of peripheral blood lymphocytes of AGN children was lower than that of the control group (P <0.05); IL-2R expression of lymphocytes activated by PHA was lower than that of the control group (P <0.005) The expression of IL-2R in stimulated lymphocytes was higher than that in control group (P <0.01). Prompted the occurrence of the disease is due to lack of function of children with T lymphocytes, decreased immune response capacity: T-B lymphocyte dysfunction, the body immune dysfunction results.