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目的探讨TTV在不同人群中的感染状况及其致病性。方法对454例人员,采用微板核酸杂交ELISA法检测TTV;血清酶测定ALT、AST和TBILI。结果454例标本中TTV阳性检出率为5.95%(27/454)。其中在肝病组检出率为3.92%(6/153),分别为肝硬化7.69%(1/13),肝癌0%(0/16),重症慢性乙肝0%(0/22),急性黄疸型乙肝11.11%(1/9),未分型急性黄疸型肝炎0%(0/2),乙肝病毒携带者4.40%(4/91)。在非肝病组检出率为6.89%(21/301),分别为新生儿高胆红素血症0%(0/25),恶性肿瘤9.76%(4/41),献血员11.0%(11/100),体检人员4.44%(6/135)。献血员和体检人员与各种疾病患者的感染率无明显差异(P>0.05);TTV感染者与未感染者的肝功能状况无明显差异(P>0.05);在肝炎患者中,感染TTV者和未感染TTV者的肝功能状况无明显差异(P>0.05)。结论在一般人群和献血员中TTV感染呈“无症状”的“携带状态”,在多种疾病患者中TTV感染无明显加重病情的作用。
Objective To investigate the infection status and pathogenicity of TTV in different populations. Methods Totally 454 individuals were tested for TTV by microplate nucleic acid hybridization (ELISA) and ALT, AST and TBILI by serum enzyme. Results The positive rate of TTV in 454 specimens was 5.95% (27/454). Among them, the detection rate in liver disease group was 3.92% (6/153), which were 7.69% (1/13) of cirrhosis, 0% (0/16) of liver cancer, 0% (0/22) of severe chronic hepatitis B, acute jaundice 11.11% (1/9) of hepatitis B, 0% (0/2) of unassigned acute jaundice hepatitis and 4.40% (4/91) of hepatitis B virus carriers. The detection rate of non-liver disease group was 6.89% (21/301), respectively, 0% (0/25) in neonatal hyperbilirubinemia, 9.76% (4/41) in malignant tumors, 11.0% / 100), 4.44% of medical staff (6/135). There were no significant differences in the infection rates between blood donors and medical staffs and patients with various diseases (P> 0.05). There was no significant difference in the liver function between patients with and without TTV infection (P> 0.05). In patients with hepatitis, those with TTV infection There was no significant difference in liver function between those with or without TTV infection (P> 0.05). Conclusion TTV infection was “asymptomatic” in the general population and blood donors in “carrying status”, and in patients with various diseases, TTV infection did not significantly aggravate the disease.