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引言硒作为人体必需的微量元素,其主要生化作用与谷胱甘肽过氧化物酶密切相关.在体内,该酶可以催化许多过氧化物的分解,并且与谷胱甘肽一起组成一个强有力的细胞防御体系,发挥其抗氧化作用.近几年来,人们发现了一种小分子有机硒化物2-苯基-1,2-苯并异硒唑酮-3(简称Ebselen)具有类似谷胱甘肽过氧化物酶的活性.它能有效地抑制活性氧自由基的产生而引起的细胞损伤,具有良好的抗炎活性,且毒性极低(大鼠LD_(50)>6180mg/os).因而,普遍认为Ebselen及其类似物是一类具有广谱抗炎活性的潜在药物,在医药领域具有广阔的应用前景.
Introduction Selenium, as an essential trace element of the human body, is closely related to glutathione peroxidase, and catalyzes the breakdown of many peroxides in vivo, and together with glutathione, constitutes a powerful Of the cell defense system to play its antioxidant role.In recent years, it has been found that a small molecule organo-selenide 2-phenyl-1,2-benzisoseptone -3 (abbreviated Ebselen) has a similar glutathione It can effectively inhibit cell injury caused by the production of reactive oxygen species, has good anti-inflammatory activity, and has very low toxicity (LD50> 6180mg / os). Therefore, it is generally accepted that Ebselen and its analogs are potential drugs with broad-spectrum anti-inflammatory activity and have broad application prospect in the field of medicine.