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目的 :了解临床心肌缺血 -再灌注过程与细胞因子间的关系。方法 :将 1 6例急性心肌梗死患者依冠状动脉是否再通分为两组 ,分别连续测定白细胞介素 - 1、白细胞介素 - 6及肿瘤坏死因子活性。结果 :溶栓后 1 2～ 48h三种细胞因子活性再通组均明显高于未通组。结论 :细胞因子活性升高与心肌缺血 -再灌注过程明显相关。
Objective: To understand the relationship between clinical myocardial ischemia-reperfusion and cytokines. Methods: The patients with acute myocardial infarction were divided into two groups according to whether the coronary arteries were recanalized. The activity of interleukin - 1, interleukin - 6 and tumor necrosis factor were measured respectively. Results: The activity of three cytokines recanalization group after 12 ~ 48h after thrombolysis was significantly higher than that of the non-through group. CONCLUSION: Elevated cytokine activity is significantly associated with myocardial ischemia-reperfusion.