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为研究加热对酵母重组乙型肝炎疫苗的反应原性和免疫原性的影响,作者选择了58名无乙型肝炎病毒感染血清学证据的健康青年(平均年龄为22.5岁),将他们随机分为试验组(27人)和对照组(31人)。试验组接种经37℃加热1周的疫苗;对照组接种同批4℃保存的疫苗。两组均分别于第0、1和6个月三角肌注射20μg疫苗。接种后记录不良反应发生情况,用放射免疫法检测接种前及接种后1、2、6和7个月血清抗-HBs滴度。结果表明,除注射部位有短暂、轻微疼
In order to investigate the effect of heating on the reactivity and immunogenicity of recombinant hepatitis B vaccines in yeast, 58 healthy, youth-free (with an average age of 22.5 years) serum-free hepatitis B virus infection were selected and randomized The experimental group (27) and the control group (31). The experimental group was inoculated with the vaccine heated at 37 ℃ for 1 week; the control group inoculated with the vaccine stored at 4 ℃ in the same batch. Both groups were injected with 20 μg of deltoid muscle at 0, 1, and 6 months respectively. The incidence of adverse reactions was recorded after inoculation, and the serum anti-HBs titers were measured by radioimmunoassay before and 1, 2, 6 and 7 months after inoculation. The results show that, in addition to the injection site has a short, mild pain