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目的：观察硝苯地平控释片（Ｎｉｆ－ＣＲ）治疗无痛性心肌缺血（ＳＭＩ）时对左心功能的影响。方法：３６例ＳＭＩ病人（男性２３例，女性１３例；年龄５６±ｓ７ａ）采用Ｎｉｆ－ＣＲ２０ｍｇ，ｐｏ，ｑ１２ｈ×３ｗｋ。结果：（１）舒张压从１２５±２．３ｋＰａ下降至９．７±２．３ｋＰａ（Ｐ＜０．０５）；缺血型ＳＴ段压低明显改善（从１．６±０．７ｍｍ升至１．０±０．６ｍｍ）（Ｐ＜０．０１）。（２）核素心功能检测，ＬＶＥＦ，ＳＶ，ＥＲ，ＰＦＲ及ＲＣＯ均显著改善（Ｐ＜０．０５或Ｐ＜０．０１）。（３）治疗后ＰＲＡ和ＡＮＧⅡ水平降低（Ｐ＜０．０５）。结论：Ｎｉｆ－ＣＲ的持久血药浓度可改善左心功能，降低血压。不良反应小。
Objective: To observe the effect of Nifedipine on left ventricular function in painless myocardial ischemia (SMI). Methods: Nif-CR20mg, po, q12h × 3wk were used in 36 SMI patients (23 males and 13 females; age 56 ± s7a). Results: (1) The diastolic blood pressure decreased from 125 ± 2.3 kPa to 9.7 ± 2.3 kPa (P <0.05); the ST segment depression in ischemic group was significantly improved (from 1.6 ± 0.7 mm to 1 .0 ± 0.6 mm) (P <0.01). (2) The cardiac function of radionuclide significantly improved LVEF, SV, ER, PFR and RCO (P <0.05 or P <0.01). (3) After treatment, the levels of PRA and ANGⅡ decreased (P <0.05). Conclusion: Long-lasting plasma concentration of Nif-CR can improve left ventricular function and lower blood pressure. Adverse reactions are small.