目的探讨急性坏死型胰腺炎（ＡＮＰ）的手术方法与手术时机．方法本组ＡＮＰ２８例以入院顺序分配为早期手术多口切开多管引流缝合组（引流组）与晚期手术病灶清除伤口敞开组（敞开组），每组均１４例，进行比较研究．结果早期胰腺引流组治愈１０例（７１４％），死亡４例（２８６％）．晚期手术胰腺坏死切除敞开引流组，全部治愈为１００％，两组治愈率有高度显著差异性（Ｐ＜００１）．结论急性坏死性胰腺炎不同病期采用不同手术可提高疗效． Objective To investigate the surgical methods and timing of acute necrotizing pancreatitis (ANP). Methods 28 cases of ANP in this group were assigned to hospital admission for the early surgical multi-ported multi-tube drainage suture drainage group (drainage group) and late surgery to clear the wound open group (open group), 14 cases in each group were compared. Results The early pancreatic drainage group was cured in 10 cases (714%) and died in 4 cases (286%). Patients with advanced pancreatic necrosis undergoing open drainage were all cured by 100%. There was a highly significant difference in the cure rates between the two groups (P <001). Conclusion Acute necrotizing pancreatitis in different stages of different operations can improve the curative effect.