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目的检测PTEN与CD44V6在不同类型子宫内膜组织中的表达情况,探讨其与内膜癌生物学行为之间的关系。方法采用免疫组织化学法(SP法)检测PTEN与CD44V6在82例子宫内膜组织中的表达。结果①PTEN在子宫内膜增生期、单纯型增生过长、复杂型增生过长、不典型增生及内膜样腺癌组织中的表达率呈显著递减趋势,而CD44V6的表达率呈递增趋势,差异有统计学意义(P<0.05);②PTEN、CD44V6的表达均与子宫内膜样腺癌的组织病理分级、手术病理分期、肌层浸润有关,差异有统计学意义(P<0.05)。结论 PTEN与CD44V6的表达在子宫内膜癌发生、发展中起一定的作用,可作为反映子宫内膜癌恶性潜能的分子标志物。
Objective To detect the expression of PTEN and CD44V6 in different types of endometrial tissues and to explore their relationship with the biological behavior of endometrial carcinoma. Methods The expression of PTEN and CD44V6 in 82 cases of endometrium was detected by immunohistochemistry (SP method). Results ① The expression of PTEN in endometrial hyperplasia, simple hyperplasia, complex hyperplasia, atypical hyperplasia and endometrial adenocarcinoma showed a significant decreasing trend, while the expression of CD44V6 showed an increasing trend, the difference (P <0.05). (2) The expressions of PTEN and CD44V6 were correlated with histopathological grade, pathological stage and myometrial invasion of endometrioid adenocarcinoma. The difference was statistically significant (P <0.05). Conclusion The expressions of PTEN and CD44V6 play a role in the development of endometrial carcinoma and may be used as molecular markers to reflect the malignant potential of endometrial cancer.