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目的研究CBA、C57BL/6bkl小鼠对脉冲性噪音损伤的敏感性。方法小鼠共分为8组,第1、2、3组为CBA小鼠(n分别为9、10、10)分别给予160dBSPL50、100、150次脉冲噪音暴露,第4、5、6组为C57BL/6bkl小鼠(n皆为10),分别给予160dBSPL50、100、150次脉冲噪音暴露,第7、8组为CBA和C57BL/6bkl小鼠对照组(n=10),无噪音暴露。在噪音暴露前、噪音后24h及28d测听觉脑干诱发电位。结果给予160dBSPL50次脉冲噪音暴露后,CBA只出现暂时性阈值漂移,C57BL/6bkl出现暂时性和永久的阈值漂移,给予160dB100次和150次脉冲噪音暴露后,CBA和C57BL/6bkl均出现暂时性和永久性阈值漂移。对照组无阈值漂移。结论C57BL/6bkl小鼠对脉冲性噪音更敏感,耳蜗铺片形态学亦支持上述结论。
Objective To investigate the sensitivity of CBA and C57BL / 6bkl mice to impulsive noise damage. Methods The mice were divided into 8 groups. CBA mice (n = 9, 10 and 10 respectively) were given 160, 100, C57BL / 6bkl mice (n = 10) were given 160, 100, and 150 pulses of noise respectively. Groups 7 and 8 were CBA and C57BL / 6bkl mice (n = 10) with no noise exposure. Before noise exposure, 24h and 28d after noise measured auditory brainstem response. Results CBA and C57BL / 6bkl showed transient and permanent threshold shifts after exposure to 160 dB SPL 50-pulse impulsive noise. CBA and C57BL / 6bkl exhibited transient and permanent threshold shifts after 160 and 100 impulse noise exposure respectively Permanent threshold shift. Control group without threshold shift. Conclusions C57BL / 6bk1 mice are more sensitive to pulsatile noise and cochlear popliteal morphology support the above conclusion.