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目的探讨乙肝大小三阳传染性,以指导孕妇孕期保健。方法选择经孕期乙肝血清学五项检测诊断为乙肝大小三阳孕妇41例,其中大三阳组18例,小三阳组23例。采用荧光定量聚合酶链反应(FQ—PCR)技术对两组孕妇血清HBV DNA进行检测,以HBV DNA≥500copies/ml作为传染性标准。记录并分析各组孕妇血清HBV DNA浓度与大小三阳的关系。结果血清HBV DNA<500copies/ml时,大三阳组1例,小三阳组17例,P<0.01;血清HBVDNA浓度为500~1e6copies/ml时,大三阳组3例,小三阳组5例,P>0.05;血清HBVDNA浓度为≥1e6copies/ml时,大三阳组14例,小三阳组2例,P<0.01。大三阳组17例传染性,占94.4%,小三阳组7例有传染性,占30.4%,P<0.01。结论大三阳孕妇94.4%有传染性,且传染性强;小三阳孕妇30.4%有传染性,且传染性弱。
Objective To explore the size of hepatitis B hepatitis B infection to guide pregnant women during pregnancy. Methods Five pregnancies of HBeAg serogroups during pregnancy were diagnosed as 41 positive hepatitis B patients with Sanyang, including 18 in Sanyang group and 23 in Sanyang group. The serum HBV DNA of two groups of pregnant women was tested by fluorescence quantitative polymerase chain reaction (FQ-PCR) technique, with HBV DNA≥500copies / ml as the infectious standard. The relationship between serum HBV DNA concentration and Sanyang of different sizes was recorded and analyzed. Results When the serum HBV DNA was less than 500copies / ml, there were 1 case in the Big Sanyang group and 17 cases in the “Small Sanyang group”, P <0.01. When HBVDNA serum concentration was 500 ~ 1e6copies / ml, , P> 0.05; when serum HBVDNA concentration was ≥1e6copies / ml, there were 14 cases in Dasanyang group and 2 cases in Xiaosanyang group, P <0.01. Seven cases of infection were found in the Sansheng group, accounting for 94.4%. Seven cases in the Sansanying group were infectious, accounting for 30.4%, P <0.01. Conclusions There are 94.4% of the pregnant women with Sanyangang are contagious and contagious; 30.4% of the pregnant women with Sanyangang are contagious and contagious.