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为探讨高血压病并靶器官损害的动态血压变化规律和特点,本文对119例高血压病患者(其中无靶器官损害者51例,并靶器官损害者68例)进行了24小时动态血压监测(ABPM)。结果显示:无靶器官损伤者血压波动曲线与正常人相似,基本呈“杓型者”(dipper)。心脑器官损害者nSBP、nDBP及nSBP/dSBP、nDBP/dDBP较无靶器官损害者明显增高,有显著性或高度显著性差异(P<0.05,P<0.01)。肾脏损害者24hSBP、24h DBP、dSBP、dDBP、nSBP、nDBP、nSBP/dSBP、nDBP/dDBP均较无靶器官损害者明显升高,有显著性或高度显著性差异(P<0.05,P<0.01)。本文表明动态血压均值和血压昼夜节律紊乱可作为高血压患者心、脑、肾靶器官损害的良好的预极因子。
In order to investigate the regularity and characteristics of ambulatory blood pressure changes in patients with hypertension and target organ damage, 119 ambulatory patients with hypertension (51 without target organ damage and 68 with target organ damage) were monitored by ambulatory blood pressure monitoring (ABPM). The results showed that the blood pressure fluctuation curve of non-target organ damage was similar to that of normal people, and was basically “dipper”. NSBP, nDBP, nSBP / dSBP and nDBP / dDBP in patients with cardiovascular and cerebrovascular diseases were significantly higher than those without target organ damage, with significant or highly significant differences (P <0.05, P <0.01). The indexes of 24hSBP, 24h DBP, dSBP, dDBP, nSBP, nDBP, nSBP / dSBP and nDBP / dDBP in renal damage group were significantly higher than those without target organ damage (P <0.05, P <0.01) ). This article shows that the mean value of ambulatory blood pressure and circadian rhythm disorders can be used as a good preconditioner for heart, brain and kidney target organ damage in hypertensive patients.