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为了探讨血清肿瘤相关抗原CEA、CA153、CA125、SCC、CY FRA21-1、NSE及SF水平与肺癌的关系,以及联合测定7项指标对肺癌早期诊断的应用价值,采用电化学发光法和化学发光微粒子免疫分析法(CMIA)分别对133例肺癌患者血清CEA、CA153、CA125、SCC、CY FRA21-1、NSE及SF水平进行检测,并与51例肺部良性疾病(BLD)患者、45名健康体检者比较。肺癌患者血清CEA、CA153、CA125、SCC、CY FRA21-1、NSE及SF水平均明显高于BLD与正常对照组(P均<0.01);CYFRA21-1敏感度在肺鳞癌组为83.78%,明显高于其他类型的肺癌(P<0.01);CEA敏感度在肺腺癌组为79.73%,明显高于其他类型的肺癌(P<0.01);NSE敏感度在小细胞肺癌组为77.27%,明显高于其他类型的肺癌(P<0.01)。7项联合检测肺癌敏感度为94.10%,可明显提高肺癌诊断的敏感度。初步研究结果提示,联合检测肺癌患者血清CEA、CA153、CA125、SCC、CY FRA21-1、NSE及SF对肺癌的早期诊断、分型具有重要的临床意义。
In order to investigate the relationship between serum tumor-associated antigens CEA, CA153, CA125, SCC, CY FRA21-1, NSE and SF and lung cancer, and to evaluate the value of 7 indicators in the early diagnosis of lung cancer, we used electrochemiluminescence and chemiluminescence The levels of CEA, CA153, CA125, SCC, CY FRA21-1, NSE and SF in 133 patients with lung cancer were detected by microparticle immunoassay (CMIA), and were compared with 51 patients with benign lung disease (BLD) Physical examination comparison. The serum levels of CEA, CA153, CA125, SCC, CY FRA21-1, NSE and SF in patients with lung cancer were significantly higher than those in patients with normal controls and BLD (all P <0.01). The sensitivity of CYFRA21-1 was 83.78% (P <0.01). The sensitivity of CEA was 79.73% in lung adenocarcinoma group, which was significantly higher than that in other types of lung cancer (P <0.01). The sensitivity of NSE in small cell lung cancer group was 77.27% Significantly higher than other types of lung cancer (P <0.01). Seven joint detection of lung cancer sensitivity was 94.10%, can significantly improve the sensitivity of lung cancer diagnosis. The preliminary results suggest that the combined detection of serum CEA, CA153, CA125, SCC, CY FRA21-1, NSE and SF in patients with lung cancer has an important clinical significance in the early diagnosis and classification of lung cancer.