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采用荧光偏振免疫法监测110例心衰患者应用地戈辛治疗过程中的血药浓度。结果表明,成人地戈辛有效药浓度范围为0.8-2ng/ml,在此范围内临床疗效佳;<0.5ng/ml则提示剂量不足,疗效差;>3.0ng/ml可结合临床诊断为洋地黄中毒。因此监测地戈辛血药浓度对了解地戈辛使用情况和防止中毒具有指导意义。
Fluorescence polarization immunoassay was used to monitor plasma concentrations of digoxin in 110 patients with heart failure. The results showed that the effective concentration of geoxin in adults ranged from 0.8 to 2 ng / ml, with good clinical efficacy in this range; <0.5 ng / ml indicated insufficient doses and poor efficacy;> 3.0 ng / ml could bind Clinical diagnosis of digitalis poisoning. Therefore, the monitoring of geoxing blood concentration is of guiding significance for understanding the use of digoxin and preventing poisoning.