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目的观察肝硬化门静脉高压引起上消化道出血患者分别应用生长抑素与垂体后叶素联合心得安的疗效比较。方法86例患者随机分成两组:A组43例,给予生长抑素250μg缓慢静脉推注,继以250μg/h微泵持续静脉滴注维持48～72 h;B组43例,给予垂体后叶素0.2 U/min静脉滴注维持72 h,心得安20 mg,每日3次口服。结果A、B两组止血有效率分别为90.4%和89.9%,P>0.05,差异无统计学意义。结论垂体后叶素联合心得安治疗肝硬化并发上消化道出血的临床疗效与生长抑素相似,说明其是治疗肝硬化并发上消化道出血的经济实用的方法。
Objective To observe the efficacy of somatostatin combined with pituitrin in combination with propranolol in patients with upper gastrointestinal hemorrhage caused by cirrhosis and portal hypertension. Methods Eighty-six patients were randomly divided into two groups: group A (n = 43), which were given a slow intravenous infusion of somatostatin (250μg), followed by continuous intravenous infusion of 250μg / h micropumps for 48-72 hours. Group B (43 cases) Prime 0.2 U / min intravenous infusion of 72 h, propranolol 20 mg, 3 times a day orally. Results The effective rates of hemostasis in groups A and B were 90.4% and 89.9%, respectively, P> 0.05, but the difference was not statistically significant. Conclusion The clinical efficacy of pituitrin combined with propranolol in treating cirrhosis complicated with upper gastrointestinal bleeding is similar to that of somatostatin, indicating that it is an economical and practical method for the treatment of upper gastrointestinal bleeding due to cirrhosis of the liver.