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目的:探讨脑局部微透析-高效液相色谱(high performance liquid chromatography,HPLC)法测定谷氨酸(glutamate,Glu)、甘氨酸(glycine,Gly)、γ-氨基丁酸(γ-aminobutyric acid,γ-GABA)、牛磺酸(taurine,Tau)含量的可行性,便秘主导型肠易激综合征[irritable bowel syndrome(IBS)with constipation,IBS-C]和腹泻主导型肠易激综合征(IBS with diarrhea