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动脉粥样硬化(AS)的发病原理仍不完全清楚。一般认为,血脂升高,动脉壁损害及血栓形成等为主要发病因素。溶酶体在AS发病学中的作用赤受到一些学者的重视。Col-toff Schiller等认为,AS的发生是由于溶酶体内水解酶活性相对不足或先天性缺乏所致,是一种溶酶体过载疾病。Shio等及Wolinsky用组化方法显示,粥样硬化病灶内溶酶体数量及活性均增加。本文拟通过家兔实验材料观察动脉粥样硬化病变的发展过程,探讨内皮细胞,尤其是平滑肌细胞(着重在其溶酶体)的改变在发病过程中的作用。
The pathogenesis of atherosclerosis (AS) is still not fully understood. Is generally believed that elevated blood lipids, arterial wall damage and thrombosis as the main risk factors. The role of lysosomes in the pathogenesis of AS has received some scholars’ attention. Col-toff Schiller so that the occurrence of AS is due to the relative lack of lysosomal hydrolase activity or a congenital lack of due to a lysosomal overload disease. Shio et al. And Wolinsky showed that the number and activity of lysosomes in atherosclerotic lesions increased with histological methods. This article intends to observe the development of atherosclerotic lesions by using experimental materials in rabbits and to explore the role of endothelial cells, especially smooth muscle cells (with emphasis on their lysosomes) in the pathogenesis.