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目的筛选疗效好、疗程短、简便、经济的治疗消化性溃疡的最佳治疗方案。方法将幽门螺杆菌（ＨＰ）相关性消化性溃疡患者，随机分为Ａ、Ｂ、Ｃ３组，分别以洛赛克、呋喃唑酮和铋剂；洛赛克和羟氨苄青霉素；法莫替丁、甲硝唑和铋剂治疗。疗程：Ａ与Ｂ组为２周，Ｃ组４周。结果各组溃疡愈合率分别为９７．６％、９０％和７５％；ＨＰ根除率分别为８５．７％、８０％和７２．２％，Ａ组和Ｃ组的愈合率有显著性差异（Ｐ＜０．０５），其余各组之间差异无显著性（Ｐ＞０．０５）。一年内３组溃疡复发率分别为１４．６％、１６．７％和３７％，ＨＰ复发率分别为１９．４％、２５％和４６．２％，Ａ组和Ｃ组的复发率有显著性差异（Ｐ＜０．０５），其余各组的复发率差异不显著（Ｐ＞０．０５）。３组ＨＰ根除者共７８例，其溃疡全部愈合（１００％），ＨＰ未根除者２０例，溃疡愈合者８例（４０％），两者有显著差异（Ｐ＜０．００５），并且其溃疡累计复发率分别为０和７．７％，亦有显著性差异（Ｐ＜０．００５）。结论Ａ组的近期和远期疗效明显优于Ｃ组而与Ｂ组相当；根除ＨＰ对消化性溃疡的愈合和防止溃疡复发均有重要作用
The purpose of screening good curative effect, short course, simple and economical treatment of peptic ulcer best treatment options. Methods Patients with peptic ulcer associated with Helicobacter pylori (HP) were randomly divided into A, B, and C3 groups, respectively, with Losec, Furazolidone and Bismuth; Losec and Amoxicillin; Famotidine, Nitrazol and bismuth treatment. Course of treatment: A and B for 2 weeks, C 4 weeks. Results The healing rates of ulcer in each group were 97.6%, 90% and 75%, respectively. The eradication rates of HP were 85.7%, 80% and 72.2% respectively. The healing rates of group A and group C were significantly different P <0.05). There was no significant difference between the other groups (P> 0.05). The recurrence rates of ulcer in three groups were 14.6%, 16.7% and 37% respectively in one year. The recurrence rates of HP were 19.4%, 25% and 46.2% respectively, and the recurrence rates of group A and C were significant (P <0.05). The recurrence rates of other groups were not significantly different (P> 0.05). There were 78 cases of HP eradication in three groups (100%), 20 cases of non-eradication HP and 8 cases (40%) of ulcer healed, both of which were significantly different (P <0.005) The cumulative ulcer recurrence rates were 0 and 7.7%, respectively, with significant differences (P <0.005). Conclusions The immediate and long-term curative effect of group A is better than that of group C and group B, respectively. Eradication of HP plays an important role in the healing of peptic ulcer and preventing the recurrence of ulcer