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目的研究玉环县≥60岁老年人群脉压差与认知功能的关系。方法采用随机整群抽样方法,在玉环县随机抽取1 700名≥60岁的常住老年人,采用简易精神状态检查量表(MMSE)对其进行认知损伤筛查,采用局部加权回归散点平滑法分析脉压差与MMSE得分之间的线性关系,采用多因素Logistic回归分析脉压差与认知功能的关系。结果共回收有效问卷1 633份,回收率为96.06%。玉环县≥60岁老年人MMSE得分平均为(23.59±5.92)分,认知损伤率为15.74%,认知损伤组脉压差为(64.01±16.31)mm Hg,高于非认知损伤组的(58.97±14.67)mm Hg(P<0.01)。局部加权回归散点平滑图显示,随着脉压差不断增大,老年人MMSE得分呈下降趋势。多因素Logistic回归分析显示,在调整部分协变量之后,老年人脉压差与认知功能存在统计关联(OR=1.010,95%CI:1.001~1.019)。结论玉环县≥60岁老年人脉压差与认知功能呈负相关,脉压差越高,认知功能表现可能越差。
Objective To study the relationship between pulse pressure difference and cognitive function in Yuhuan County. Methods A random cluster sampling method was used to randomly select 1,700 elderly people aged ≥60 years in Yuhuan County. The MMSE was used to screen for cognitive impairment. The local weighted regression scatter smooth The linear relationship between pulse pressure and MMSE score was analyzed. The relationship between pulse pressure and cognitive function was analyzed by multivariate Logistic regression. Results A total of 1 633 valid questionnaires were collected and the recovery rate was 96.06%. The average MMSE score of ≥60-year-olds in Yuhuan County was (23.59 ± 5.92) points, the cognitive impairment rate was 15.74%, and the difference of pulse pressure in cognitive impairment group was (64.01 ± 16.31) mm Hg, higher than that in non-cognitive impairment group (58.97 ± 14.67) mm Hg (P <0.01). The scatter plot of local weighted regression shows that MMSE scores of elderly people show a decreasing trend as the pulse pressure difference increases. Multivariate logistic regression analysis showed that after adjusting for some covariates, there was a statistical correlation between pulse pressure and cognitive function in the elderly (OR = 1.010, 95% CI: 1.001-1.019). Conclusion The pulse pressure difference of cognitive impairment is negatively correlated with cognitive function in Yuhuan County. The higher the pulse pressure difference, the worse cognitive function may be.