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痛风导致的肾脏损害称为“痛风性肾病”。痛风常有明显的关节炎症状,而肾脏改变常常是隐匿的,既可出现在痛风关节炎反复发作多年后,也有肾脏损害发生在关节炎之前。痛风肾脏损害有慢性痛风性肾病、急性梗阻性肾病及尿路尿酸结石。慢性痛风性肾病是最常见的肾脏损害,主要是因为高尿酸血症造成肾脏过度排泄尿酸而引起尿酸盐结晶沉积于肾脏组织。沉积的部位主要是肾间质组织,导致间质性肾炎,也可阻塞肾集合管。临床上所谓的痛风性肾病大多非单纯的高尿酸
Gout-induced kidney damage is called “gouty kidney disease.” Gout often has obvious symptoms of arthritis, and kidney changes are often occult, both after repeated episodes of gouty arthritis and kidney damage occurs before arthritis. Gout kidney damage chronic gouty kidney disease, acute obstructive nephropathy and urinary tract stones. Chronic gouty kidney disease is the most common kidney damage, mainly due to hyperuricemia caused by excessive renal excretion of uric acid caused by urate crystals deposited in the kidney tissue. The site of deposition is mainly interstitial renal tissue, leading to interstitial nephritis, but also can block the renal collecting tube. Clinically so-called gouty kidney disease are mostly not purely high uric acid