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目的:探讨精索原发性Burkitt淋巴瘤的临床病理特征。方法:运用组织病理学和免疫组织化学方法研究1例原发于精索的Burkitt淋巴瘤,并复习临床资料及文献。结果:男性患儿,4岁。偶尔发现阴囊处肿块1个月。术中见肿块位于左侧精索,大小5cm×3cm×2cm,切面灰红,鱼肉样。组织学:瘤组织由单一的、弥漫浸润的中等大小圆细胞组成,其中散在分布着吞噬细胞碎片的组织细胞,呈“星空样”改变。免疫表型:瘤细胞弥漫表达CD20和CD79,部分表达CD10,约95%的瘤细胞Ki-67阳性。瘤细胞不表达CD3、CD43、bcl-2和TdT。EBV原位杂交:瘤细胞阴性。结论:原发于精索的Burkitt淋巴瘤非常罕见,此型淋巴瘤高度恶性,预后较差。确诊依赖于病理组织学与免疫组化标记,并且该肿瘤要与其他类型的淋巴瘤及非淋巴系统的小细胞恶性肿瘤相鉴别。
Objective: To investigate the clinicopathological features of primary Burkitt’s lymphoma in spermatic cord. Methods: One case of Burkitt lymphoma with primary spermatic cord was studied by histopathology and immunohistochemistry. Clinical data and literature were reviewed. Results: Male children, 4 years old. Occasionally found the scrotum at 1 month. Intraoperative see the mass located on the left spermatic cord, the size of 5cm × 3cm × 2cm, cut red and gray, fish-like. Histology: Tumor tissue consists of a single, diffuse infiltration of medium-sized round cells, scattered in the distribution of phagocytic cells of the tissue cells, was “star-like” changes. Immunophenotype: tumor cells diffusely express CD20 and CD79, partially express CD10, and about 95% of Ki-67 positive tumor cells. Tumor cells do not express CD3, CD43, bcl-2 and TdT. EBV in situ hybridization: tumor cells negative. Conclusion: Burkitt’s lymphoma, which originates from spermatic cord, is very rare. This type of lymphoma is highly malignant with poor prognosis. Confirmation depends on histopathology and immunohistochemical markers, and the tumor with other types of lymphoma and non-lymphoid small cell malignant tumor phase identification.