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作者对内镜证明的食管病变,采用甲氰咪胍800mg,2次/d进行治疗,并用多中心、随机、双盲、安慰剂对照试验进行评价。有93例患者随机采用甲氰咪胍治疗,而另外86例采用安慰剂治疗。内镜检查在治疗前及治疗后6周及12周进行。并使用Kaplan-Meier方法判断治愈率。结果表明,用甲氰咪胍治疗中度损伤病例,治愈率76%,安慰剂治愈率41%,两组有明显差别(P<0.01);而治疗重度病变时,甲氰咪胍的治愈率为56%,而安慰剂为29%,仍有显著差别(P<0.05)。
The authors evaluated endopharyngeal esophageal lesions using cromolyn 800 mg twice daily for evaluation and in a multicenter, randomized, double-blind, placebo-controlled trial. Ninety-three patients were randomized to cimetidine, while the other 86 were treated with placebo. Endoscopy was performed before and 6 and 12 weeks after treatment. The Kaplan-Meier method was used to determine the cure rate. The results showed that, in the treatment of moderate injury with cimetidine, the cure rate was 76% and the placebo cure rate was 41%, there was a significant difference between the two groups (P <0.01); while in the treatment of severe disease, the cure rate of cimetidine Compared with 56% for placebo and 29% for placebo (P <0.05).