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Objective: By observing the pattern of the focal liver lesions (FLL) in different phases by real time contrast-enhanced ultrasound (CEUS), compared to enhanced CT, investigate the value of CEUS in diagnosing focal liver lesions. Methods: 35 patients with unconfirmed focal liver lesions were studied by contrast agent SonoVue and Technos DU 8 produced by Esaote company. Results: Among the 14 cases of hepatocellular carcinoma (HCC), 10 were typical, presented with early artery enhancement and immediate wash-out. The enhancement patterns of 6 livers metastasis were diverse, including peripheral or entire degree enhancement. The wash-out time in malignant tumors was earlier than other focal liver lesions (P<0.05), appeared as hypoechoic in the portal phase or parenchyma phase. The 6 cases of hemangioma were enhanced centripetally nodular in artery phase and washed out after several minutes. The pattems of different lesions were similar compared to contrast-enhanced CT, without significant statistic differences. Conclusion: The contrast enhanced ultrasound technique can significantly improved the value of diagnosing focal liver lesions.