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目的观察鼠神经生长因子(NGF)联合脑蛋白水解物治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法 90例HIE患儿随机分为观察组及对照组,各45例,观察组在常规综合治疗的基础上联合使用鼠神经生长因子及脑蛋白水解物治疗;对照组在常规综合治疗的基础上联合胞二磷胆碱治疗,观察两组患儿在治疗1周内呼吸、肌张力、惊厥及意识障碍等的改善情况,进行疗效评定,于治疗前及治疗2周后按照新生儿神经行为(NBNA)评分标准对两组患儿进行评分。结果观察组总有效率(93.3%)明显高于对照组(73.3%)(P<0.05)。两组患儿治疗前NBNA评分,差异无统计学意义(P>0.05),治疗2周后观察组总有效率明显高于对照组(P<0.05)。结论鼠神经生长因子联合脑蛋白水解物治疗新生儿缺氧缺血性脑病能减轻急性脑损伤,促进脑功能的恢复,疗效显著,是早期干预治疗HIE的积极方法。
Objective To observe the clinical efficacy of nerve growth factor (NGF) combined with brain protein hydrolyzate in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Ninety children with HIE were randomly divided into observation group (45 cases) and control group (n = 45). The observation group was treated with combination of nerve growth factor and brain protein hydrolyzate on the basis of conventional comprehensive treatment. On the basis of conventional comprehensive treatment Combined with citicoline treatment, observed in two groups of children within 1 week of treatment of respiration, muscle tension, convulsions and disturbance of consciousness, etc., to assess the efficacy, before treatment and 2 weeks after treatment in accordance with neonatal neurological behavior ( NBNA) score standard two groups of children score. Results The total effective rate (93.3%) in observation group was significantly higher than that in control group (73.3%) (P <0.05). There was no significant difference in NBNA score between the two groups before treatment (P> 0.05). After 2 weeks of treatment, the total effective rate of the observation group was significantly higher than that of the control group (P <0.05). Conclusions The treatment of neonatal hypoxic-ischemic encephalopathy with NGF and brain hydrolysates can reduce acute brain injury and promote the recovery of brain function with significant curative effect. It is an active method for early intervention in the treatment of HIE.