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为了确定肾病综合征患者是否加速冠状动脉粥样硬化的发生,作者对比肾病综合征与对照患者的临床及冠状动脉主支的病理观察。 20例肾病综合征,年龄15～35岁,平均24岁。其中系统性红斑狼疮13例,糖尿病4例,慢性肾小球肾炎3例。均有高胆固醇血症,最高血清总胆固醇平均423毫克％。19例有高血压。曾用皮质类固醇治疗,疗程平均39月。8例有充血性心衰,均无典型的缺血性胸痛,心电图均无心肌梗塞表现。 14例对照患者,年龄20～39岁,平均29岁。其中白血病5例,癌6例,肉瘤2例,中暑1例。均无心肾功能不全、心脏、高血压、高胆固醇血症及肾脏疾病。尸检冠状动脉结果:四支冠状动脉(包括右冠状动脉、左冠状动脉的主干、左旋支及左前降支)中有
In order to determine if patients with nephrotic syndrome may accelerate the development of coronary atherosclerosis, the authors compared the clinical features of the nephrotic syndrome with that of the control patients and the pathology of the main coronary artery. 20 cases of nephrotic syndrome, aged 15 to 35 years, mean 24 years old. 13 cases of systemic lupus erythematosus, 4 cases of diabetes, 3 cases of chronic glomerulonephritis. Have hypercholesterolemia, the highest serum total cholesterol 423 mg%. 19 cases of hypertension. Corticosteroids have been used to treat an average of 39 months. 8 cases of congestive heart failure, no typical ischemic chest pain, ECG showed no myocardial infarction. 14 cases of control patients, aged 20 to 39 years, mean 29 years. Including leukemia in 5 cases, 6 cases of cancer, sarcoma in 2 cases, 1 case of heat stroke. No heart and kidney dysfunction, heart, high blood pressure, hypercholesterolemia and kidney disease. Autopsy Coronary Artery Results: Of the four coronary arteries (including the right coronary artery, the trunk of the left coronary artery, the left circumflex artery and the left anterior descending artery)