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目的:探讨人类白细胞抗原G(HLA-G)蛋白在正常妊娠和原因不明习惯性流产绒毛滋养细胞中的表达及其与两者的关系。方法:采用免疫组化法检测HLA-G蛋白在原因不明习惯性流产组(n=19)和正常妊娠组(对照组)(n=29)的表达情况。结果:HLA-G在原因不明习惯性流产组的表达明显低于对照组,差异有统计学意义(P<0.01)。结论:HLA-G蛋白的表达下调可能是原因不明习惯性流产发生的因素。
Objective: To investigate the expression of human leukocyte antigen G (HLA-G) protein in normal pregnancy and unexplained habitual abortion villus trophoblast cells and its relationship with them. Methods: Immunohistochemistry was used to detect the expression of HLA-G protein in unexplained habitual abortion group (n = 19) and normal pregnancy group (n = 29). Results: The expression of HLA-G in the unexplained habitual abortion group was significantly lower than that in the control group (P <0.01). Conclusion: The down-regulation of HLA-G protein may be the reason of unexplained habitual abortion.