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本实验观察了大鼠黑质网状部（ＳＮＲ）微量注射Ｐ物质（ＳＰ，１０ｕｇ／０．２ｕｌ）对黑质多巴胺能和非多巴胺能神经元单位放电活动的影响。结果如下：（１）在记录的２６个多巴胺能神经元之中，有８个单位自发放电频率增加为３１．００－１１７．７７％，平均５４．７８±１０．９９％（ｘ±ｓｘ），９个单位自发放电频率减少为５１．５７－１００．００％，平均７５．５５±６．８５％。（２）对在记录的４２个非多巴胺能神经元中有１９个单位自发放电频率增加为３４．６９－１１８．９２％，平均６３．９６±７．８１％。１３个单位为３３．１０－９６．８６％自发放电频率减少，平均６２．１３±５．５４％。结果表明，Ｐ物质对黑质多巴胺能和非多巴胺能神经元既有兴奋作用也有抑制作用。
In this study, we investigated the effects of substance P (10ug / 0.2ul) injected into substantia nigra mesh (SNR) on the activity of dopaminergic and non-dopaminergic neurons in substantia nigra. The results were as follows: (1) Among the 26 dopaminergic neurons recorded, the spontaneous firing frequency of 8 units increased from 31.00% to 117.77% with an average of 54.78 ± 10.99% (x ± sx) , Spontaneous discharge frequency of nine units decreased to 51.57-100.00%, with an average of 75.55 ± 6.85%. (2) For the 42 non-dopaminergic neurons recorded, the spontaneous firing frequency of 19 units increased from 34.69 to 18.92%, with an average of 63.96 ± 7.81%. 13 units of 33.10-96.86% spontaneous discharge frequency decreased, with an average of 62.13 ± 5.54%. The results showed that substance P also inhibited both substantia nigra dopaminergic and non-dopaminergic neurons.