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目的分析上海市医院门诊就诊女性宫颈人乳头瘤病毒(HPV)感染状况及亚型分布特点。方法收集2009年5月—2012年12月在上海市第八人民医院门诊就诊的2 701例女性宫颈HPV检测资料,对HPV感染现状及亚型分布特点进行分析。结果检出21种HPV亚型,总感染率为33.65%,感染率最高的亚型是HPV16(6.85%)和HPV52(6.85%),其他常见亚型为HPV58(6.18%)、HPV53(3.74%)和HPV11(3.70%);16~45岁感染数占总感染数的83.82%,各年龄组感染率差异有统计学意义,低年龄组(16~25岁)感染率最高(36.82%),高年龄组(≥66岁)最低(16.36%);个体感染亚型种类数最多检出7种,单一亚型感染率为22.84%,多重感染率为10.81%,高危型感染率为24.58%,低危型为4.59%,高低危混合型为4.48%;高危型感染中以26~35岁感染率最高,低危型感染以16~25岁最高,混合型感染以≥66岁最高。结论上海市医院就诊女性宫颈HPV感染最常见亚型为HPV16、HPV52、HPV58、HPV53和HPV11,感染呈现以单一亚型、高危感染和16~45岁感染为主,多重感染并存的特征。
Objective To analyze the status and subtype distribution of female cervical HPV infection in outpatient department of Shanghai hospital. Methods The data of 2 701 cervical HPV tests from May 2009 to December 2012 in Outpatient Department of Shanghai Eighth People ’s Hospital were collected to analyze the status and subtypes of HPV infection. Results Twenty-one HPV subtypes were detected with a total infection rate of 33.65%. The highest subtypes were HPV16 (6.85%) and HPV52 (6.85%). Other common subtypes were HPV58 (6.18%), HPV53 ) And HPV11 (3.70%). The infection rate of 16-45 years old was 83.82% of the total number of infection, the infection rate of each age group was statistically significant, the infection rate of the lowest age group (16-25 years old) was the highest (36.82% The highest number of individuals (≥66 years) was the lowest (16.36%). The highest number of subtypes was detected in 7 individuals, the single subtype was 22.84%, the multiple infection rate was 10.81%, the high-risk infection rate was 24.58% The low-risk type was 4.59%, while the high-low-risk type was 4.48%. The highest infection rate was 26-35 years in high-risk type, the highest was in 16-25 years in low-risk type, and the highest was ≥66 years in mixed type. Conclusions The most common cervical subtype of HPV infection in Shanghai hospital is HPV16, HPV52, HPV58, HPV53 and HPV11. The infection is characterized by single subtype, high-risk infection and infection of 16-45 years old, and multiple infections coexist.